Regarded as "arguably Italy's finest Verdi tenor" by the American magazine Metropolitan Opera Guild and praised for his bright timbre, dazzling high notes, and crystal-clear diction, Luciano Ganci took his first steps in music by joining the Choir of the Pontifical Sistine Chapel Music directed by Maestro Domenico Bartolucci. He studied singing, piano, and organ, combining his musical studies with technical-scientific studies, earning degrees in surveying and finally in urban planning and territorial planning.

Since 2006, he has been studying opera singing, mainly refining his skills under the guidance of Otello Felici. Winner and awardee of the Ottavio Ziino, Rolando Nicolosi, Iris Adami Corradetti competitions, he has been awarded the Giuseppe Verdi International Prize and the International Opera Award – Opera Oscar, as a young promise.

Active since 2009, he made his debuts in Le Nozze di Figaro and Gianni Schicchi, followed by his first performances as Alfredo in La Traviata in 2010, followed by the Puccini roles of Rodolfo in La Bohème and Pinkerton in Madama Butterfly, Oronte in I Lombardi alla prima crociata, and Turiddu in Cavalleria rusticana. In 2012, he made his international debut in La Traviata in Salzburg. A few months later, he debuted in L'amico Fritz, Christus am Ölberge by Beethoven, Mozart's Requiem, and Il Trovatore. Also in 2012, he recorded a disc of unreleased Mascagni pieces for the Chandos label. Since then, his debuts have continued with Il Corsaro  (for the inauguration of the season at the Teatro Verdi in Trieste), Nabucco (at the NCPA in Beijing), Attila (inauguration of the new theater in Astana, Kazakhstan), and Verdi's Requiem in 2013; Mario Cavaradossi in Tosca, Macduff in Macbeth, and Beethoven's IX Symphony in 2014; Rodolfo in Luisa Miller (Teatro San Carlo in Naples), Amenofi in Rossini's Mosè (available on DVD), and Pollione in Norma in 2015; Carlo VII in Giovanna d'Arco at the Verdi Festival in Parma (also on DVD) in 2016; Gustavo III in Un ballo in maschera, the Duke of Mantua in Rigoletto, and the title role in Stiffelio by Verdi at the Verdi Festival in Parma (available on DVD), Puccini's Messa di Gloria, and Don José in Carmen in 2017. The following year, he debuted as Malatestino in Francesca da Rimini at La Scala in Milan, Edgardo in Lucia di Lammermoor at the Teatro Carlo Felice in Genoa, and Rossini's Petite Messe Solennelle. In 2019, he debuted for the first time as Don Alvaro in La forza del destino in Piacenza and as Andrea Chénier in the title role at the opera in Nice. In 2020, he debuted as Radamès in Aida at the Liceu Theater in Barcelona, and in 2021 as Maurizio di Sassonia in Adriana Lecouvreur at the Teatro Comunale in Bologna, performing in the Gala reopening of the Ponchielli Theater in Cremona, as Radamès in the inaugural Aida of the centenary of the Macerata Opera Festival, and debuted as Loris Ipanov in Fedora by Giordano at the Concertgebouw in Amsterdam. Also in 2021, he debuted as Oberto in Edmea by Catalani at the Wexford Festival Opera and sang for the first time at the Vienna State Opera both in Adriana Lecouvreur and in Tosca. In 2022, he debuted as Aroldo in Verdi's eponymous opera in the theaters of Ravenna, Piacenza, and Modena, Roberto in Le Villi at the Halle aux Grains in Toulouse, he sang for the first time in Italy as Andrea Chénier at the Teatro Comunale in Bologna and as Zamoro in Alzira at the Opéra Royal de Wallonie-Liège. Finally, he debuted at the Rome Opera, singing in his distinctive role of Cavaradossi. In 2023, he returned to the Rome opera house with the roles of Radamès in Aida, Canio in Pagliacci, debuting the latter after recording it, and F.B.Pinkerton in Madama Butterfly; he later debuted the role of Ildemaro in the world premiere of Donizetti's opera Dalinda in Berlin and sang for the first time at the Bavarian State Opera in Aida. In October, he debuted on stage as Loris Ipanov in Umberto Giordano's Fedora and in November debuted as Gabriele Adorno in Verdi's Simon Boccanegra at the New National Opera in Tokyo. He ended the year with Verdi's Requiem in Ankara and Un ballo in maschera at the Verona Philharmonic Theater. 

In 2024, he inaugurates the season at the Teatro Comunale in Bologna, debuting the role of the Cavaliere Des Grieux in Giacomo Puccini's Manon Lescaut; he debuts at the Den Norske Opera in Oslo with Madama Butterfly and subsequently sings for the first time at the Salzburg Festival, interpreting Verdi's Requiem conducted by Antonio Pappano with the Accademia Nazionale di Santa Cecilia. In April, he is Radamès in Aida at the Tokyo Spring Festival conducted by Riccardo Muti at the Bunka Kaikan.

He has sung in the most prestigious theaters, from La Scala to San Carlo, Rome Opera, Arena di Verona, Vienna State Opera, Bavarian State Opera, Bologna Municipal Theater, Teatro Massimo in Palermo, Maggio Musicale Fiorentino Theater, Regio Theater and Verdi Festival in Parma, Haus Fur Mozart in Salzburg and Opera House in Graz, Berlin Konzerthaus, Palau des Art de la Reina Sofia in Valencia, Gran Liceu in Barcelona, Sferisterio in Macerata, Petruzzelli in Bari, Herodes Atticus in Athens, Edmonton Opera in Canada, Bolshoi and Mariinsky in Russia, Opera in Antwerp and Ghent in Belgium, Royal Opera in Muscat in Oman, Abu Dhabi Theater in the United Arab Emirates, Astana Theater in Kazakhstan, NCPA in Beijing, New National Opera Tokyo and Hyogo Opera Festival in Japan, Art Center in Seoul, and at the Spring Festival in Budapest. He has held concerts and recitals in Rome, Naples, Parma, Carrara, Milan, Brescia, Padua, Ancona, Perugia, Lucca, Verona, Busseto, as well as in India, Canada, Switzerland, Slovenia, Czech Republic, Korea, Japan, Hungary, Oman, Malta, Ukraine, and Russia.